The church of San Fedele originated with the hospitalis of the same name, which was built after 1270 thanks to a substantial donation from Ranieri degli Olivi.
The institute belonged to a company of disciplined men, as is written on the 15th-century lintel of the church portal. Documents in the municipal historical archives confirm that it was owned by the Confraternita del Gonfalone.
The church has a single nave, which was completely transformed in the 17th century in a rather subtle Baroque style. Recent restoration work has revealed traces of Renaissance decoration in the cavities of the side walls. Of particular value is a fresco in a niche next to the entrance door depicting the Virgin between St. Sebastian and St. Roch, attributed to the school of Luca Signorelli. On the walls, you can see the grates through which the nuns of the adjacent monastery of Santa Caterina attended the celebrations. After the hospital closed in 1757 and with the suppression of religious orders following the unification of Italy, buildings and assets were expropriated by the state, and ownership passed to the municipality. The portable works of art from this church are now kept in the Municipal Museum of San Francesco.
The church of San Fedele now houses the Municipal Auditorium. In 2022, the organ from the Church of San Francesco dei Frati Minori Conventuali was relocated here after extensive restoration. It was built in 1828 and is an early work by the famous Perugian craftsman Angelo Morettini, who was 29 at the time, and commissioned by Father Francesco Cesarini, guardian of the convent.